Y chromosome-a tool in infertility studies of Latvian population.

A. Puzuka, N. Pronina, I. Grinfelde, J. Erenpreiss, V. Lejins, J. Bars, L. Pliss, I. Pelnena, V. Baumanis, A. Krumina

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Human Y chromosome is used as a tool in male infertility and population genetic studies. The aims of this research were to analyse the prevalence of Y chromosome microdeletions among infertile Latvian men, and to identify possible lineages of Y chromosome that may be at increased risk of developing infertility. A study encompassed 105 infertile men with different spermatogenic disturbances. Deletions on Y chromosome were detected in 5 out of 105 (approximately 5%) cases analysed in this study. Three of them carried deletion in AZFc region and two individuals had AZFa + b + c deletion. Study of Y chromosome haplogroups showed that N3a1 and R1a1 lineages were found less frequently in the infertile male group compared to ethnic Latvian group, however K* cluster was predominantly found in infertile male Y chromosomes. Conclusions: 1) Our study advocates running Y chromosome microdeletion analyses only in cases of severe form of infertility; 2) Y chromosome haplogroup analysis showed statistically significant tendencies that some haplogroups are more common in ethnic male group, but others are more common in infertile males.

Original languageEnglish
Pages (from-to)394-400
Number of pages7
JournalGenetika (Moskva)
Issue number3
Publication statusPublished - Mar 2011

Field of Science*

  • 1.6 Biological sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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