Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses

E. Aleksejeva, A. Houel, V. Briolat, J. P. Levraud, C. Langevin, P. Boudinot

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms.

Original languageEnglish
Pages (from-to)48-56
Number of pages9
JournalDevelopmental and Comparative Immunology
Volume57
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

Keywords

  • Antiviral innate immunity
  • Interferon
  • PLZF
  • ZBTB
  • Zebrafish

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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